Published in Hepatitis Weekly, August 19th, 1996
A confounding factor in the detection of hepatitis C virus (HCV) by in situ hybridization techniques is the diversity of viral isolates. It has been estimated that among different viral isolates, RNA sequences can vary by as much as 21 percent. This finding has provided the basis on which viral isolates are categorized within the classification system proposed by Simmonds et al. (J Gen Virol 1993;74:2391).
However, certain regions of the viral genome, especially those...
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