Therapy (HBV)

"Interferon-Alpha Therapy for Chronic Hepatitis B in Children: A Meta-Analysis."

Published in Hepatitis Weekly, August 19th, 1996

According to the authors' abstract of an article published in Clinical Infectious Diseases, "A meta-analysis of six randomized clinical trials involving 240 children with chronic hepatitis B treated with recombinant interferon-alpha (IFN-alpha) was performed. IFN-alpha treatment was effective in blocking viral replication. Clearance of hepatitis B virus (HBV) DNA from sera occurred in 44 of 127 treated patients (P<.00001), and clearance of hepatitis B e antigen (HBeAg) occurred in seven of 74 treated patients (P=.099). IFN-alpha normalized serum levels of alanine aminotransferase (ALT) in 33 of 85 treated patients (P=.017). At the end of the follow-up period,...

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Source: Hepatitis Weekly (1996-08-19)

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