Virology (HCV)

Hepatitis C Quasispecies Heterogeneity Studied

Published in Hepatitis Weekly, September 9th, 1996

The estimated duration of hepatitis C virus (HCV) carriage, serum HCV RNA levels, and HCV type 1 are important determinants for the evolution of HCV quasispecies heterogeneity, according to a multicenter report.

Researcher Regino P. Gonzalez-Peralta and colleagues also found that increased HCV quasispecies heterogeneity is a marker associated with a poor response to interferon-(alpha) therapy.

Determination of quasispecies heterogeneity by conventional cloning and sequencing techniques is labor intensive and expensive. For this reason, analysis of a large number of clinical samples has been impractical, as are extensive clinical studies.

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Source: Hepatitis Weekly (1996-09-09)

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