Disease Markers (HCV)

Region A of HCV NS3 Distinguishes Between Hepatitis and Cirrhosis

Published in Hepatitis Weekly, September 30th, 1996

Region A within the NS3 protein of the hepatitis C virus may be a useful prognostic marker to differentiate chronic hepatitis from cirrhosis, according to a report from Taiwan.

Infection with hepatitis C virus (HCV) is usually detected through the presence of antibodies to the viral antigens. In previous studies it has been suggested that the most common antibodies are those against HCV C22 (core), C33C (NS3), and ns5 (NS5) polypeptides. Among them, anti-C33C yields the highest detection rate, indicating that NS3 protein is an immunodominant antigen.

"The HCV NS3 protein encodes viral protease and helicase," researcher Lih-Hwa Hwang and colleagues...

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Source: Hepatitis Weekly (1996-09-30)

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