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Therapy (HBV)

IFN-(alpha) Does Not Promote Autoantibody Development

Published in Hepatitis Weekly, October 7th, 1996

Autoantibodies are common in hepatitis B virus infection but their prevalence is not influenced by interferon alpha, according to a report from the United Kingdom.

Interferon alfa (IFN-(alpha)) is the most successful drug currently in use for the treatment of liver disease caused by chronic hepatitis infection. Its most common side effect is an influenza-like syndrome that usually disappears after the first few treatment doses. Other possible toxicities, however, such as the induction of autoimmunity, are more dangerous.

"Autoimmune phenomena ranging from appearance of tissue autoantibodies to overt autoimmune disease, such as thyroiditis, systemic...

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