Pathogenesis (HAV)

Cellular Receptor for Hepatitis A Identified

Published in Hepatitis Weekly, October 21st, 1996

A cellular receptor for hepatitis A virus has been identified for the first time by officials with the U.S. Food and Drug Administration.

The receptor involves a surface glycoprotein on African green monkey kidney cells ("Identification of a Surface Glycoprotein on African Green Monkey Kidney Cells as a Receptor for HAV," The EMBO Journal, August 15, 1996;4282-4296).

Little is known about the mechanism of cell entry of hepatitis A virus (HAV).

"Early work characterizing cellular receptors for HAV showed that HAV infectivity in tissue culture required calcium and was inhibited by treatment of the cells with trypsin, phospholipases...

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Source: Hepatitis Weekly (1996-10-21)

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