Published in Hepatitis Weekly, October 28th, 1996
It is generally believed that immune-mediated mechanisms, such as HLA class I-restricted cytotoxic T lymphocytes (CTL), play an important role in viral clearance and disease pathogenesis in many viral infections. In hepatitis C virus infection, however, HLA class I-restricted HCV specific CD8+ CTL are detectable in the peripheral blood and CTL clones have been isolated from the liver of...
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