"Nonrheumatoid IgM in Human Hepatitis C Virus-Associated Type II Cryoglobulinemia Recognize Mimotopes of the CD4-Like LAG-3 Protein."

According to the authors' abstract of an article published in Journal of Immunology, "Type II mixed cryoglobulinemia (CryoII) is an autoimmune disorder frequently associated to human hepatitis C virus (HCV) infection and characterized by the presence of cold-insoluble immunocomplexes containing IgM with rheumatoid activity. To identify disease-related epitopes, we screened a phage-displayed random peptide library using purified IgM from patients with HCV-associated CryoII (CryoII/HCV). A dominant population of phage isolates bearing the HPLAP pentapeptide consensus motif was identified and shown to be recognized by a nonrheumatoid IgM species strongly associated to CryoII/HCV. The...

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