Carcinogenesis (HBV)

Chromosome 8p Loss Common in HBV+ HCC Patients

Published in Hepatitis Weekly, December 16th, 1996

A Chinese study showing a frequent loss of chromosome 8p in hepatitis B virus-positive hepatocellular carcinoma (HCC) patients may shed light on the association between hepatitis and cancer.

Researcher Sherry A. Becker and colleagues suggest that viral integration sites associated with gross chromosomal alterations may serve as markers identifying regions of the cellular genome harboring tumor suppressor genes whose loss is important to hepatocarcinogenesis.

The role of hepatitis virus in tumor formation appears to be complex and may involve both direct and indirect mechanisms. The majority of HCCs from HBV endemic areas contain integrated virus...

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Source: Hepatitis Weekly (1996-12-16)

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