Therapy (TB)

Hydrazine Related to Isoniazid Liver Toxicity

Published in Hepatitis Weekly, December 16th, 1996

Hydrazine may be the metabolite of the antituberculosis agent isoniazid responsible for liver necrosis, according to a report from British Columbia.

Isoniazid is an indispensable agent for the chemoprophylaxis and treatment of tuberculosis, but daily administration has been found to be hepatotoxic in between one and two percent of patients receiving the drug. This hepatotoxicity can be fatal if not recognized early.

The mechanism of isoniazid-induced hepatotoxicity is not currently known, and most previous research has focused on a rat model with the hypothesis that acetylhydrazine, a metabolite of isoniazid, is the cause of this toxicity.

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Source: Hepatitis Weekly (1996-12-16)

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