Drug-Induced Hepatitis

Flutamide-Induced Hepatitis Treated with UDCA

Published in Hepatitis Weekly, February 3rd, 1997

Italian researchers recently reported the successful treatment of a case of flutamide-induced toxic hepatitis using ursodeoxycholic acid (UDCA).

"Since fatal flutamide-related hepatitis has been reported, monitoring of serum liver tests is advocated during flutamide administration, and the effectiveness of UDCA in the treatment of drug-induced hepatoxicity requires further study," researcher Camilla Cicognani and colleagues wrote ("Flutamide-Induced Toxic Hepatitis," Digestive Diseases and Sciences, November 1996;41(11):2219-2221).

Flutamide (4' nitro-3'-trifluoromethyl-isobutylanilide) is a nonsteroidal antiandrogen commonly used in the treatment of...

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Source: Hepatitis Weekly (1997-02-03)

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