Drug Resistance (HBV)
"Frequency of Antibody Resistant Mutants among Mothers and Infants with Chronic Hepatitis B Virus (HBV) Infection."
Published in Hepatitis Weekly, February 17th, 1997
According to an abstract submitted by the authors to the 10th International Congress of Virology, held August 11-16, 1996, in Jerusalem, Israel, "Hepatitis B surface antigen (HBsAg) is the major envelope protein of HBV. Antibody to HBsAg (anti-HBs) binds to the a determinant region at aa positions 124 to 147. The a determinant is highly conserved at the amino acid level and changes could produce variants resistant to anti-HBs neutralization. The frequency of these mutations was determined by direct sequencing of PCR amplicons from infants who failed postexposure prophylaxis, as well as their mothers. Of the 80 infants analyzed, 15 were found to have one or more amino acid changes in...
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Source: Hepatitis Weekly (1997-02-17)
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