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Conference Coverage (Hepatitis)

RNA Aptamers Specific to NS3 of HCV Isolated

Published in Hepatitis Weekly, February 17th, 1997

Researchers in Japan have isolated RNA aptamers specific to the NS3 protease domain of hepatitis C virus from a pool of completely random RNA.

P.K.R. Kumar and colleagues suggested the finding could be important in the search for inhibitors of the NS3 protease. They presented their findings at the International Business Communications conference, "Hepatitis: Latest Therapeutic Developments for Hepatitis B and C," held January 30-31, 1997 in Washington D.C.

Hepatitis C virus is a single-stranded RNA virus and its genome is translated into a single large polyprotein. The viral encoded NS3 proteases are necessary for processing the polyprotein. ...

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