Genetic Domain (HBV)
"New Mutational Hot-Spot in Hepatitis B Virus DNA: Coincides with T-Cell Domain of Residue 28-51."
Published in Hepatitis Weekly, March 3rd, 1997
According to an abstract submitted by the authors to the 1997 Annual Meeting of the United States and Canadian Academy of Pathology, held March 1-7, 1997, in Orlando, Florida, "Background: Protective immunity induced by vaccination with hepatitis B virus surface antigen (HBsAg) is associated with production of a neutralizing antibody (anti-HBsAb) against 'group a determinant (B-cell epitope)'. Vaccine failure due to immune escape mutations (IEM) has been reported within this B-cell domain of amino acid residue 124-148 but not within the T-cell domain. To investigate IEM of HBV DNA, we examined and sequenced the entire HBsAg gene from liver samples with hepatocellular carcinoma...
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Source: Hepatitis Weekly (1997-03-03)
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