Transplantation (HBV)
"Evidence for Selection of Hepatitis B Mutants after Liver Transplantation Through Peripheral Blood Mononuclear Cell Infection."
Published in Hepatitis Weekly, March 31st, 1997
According to the authors' abstract of an article published in Journal of Hepatology, "Background/Aims: Despite anti-HBs immunoglobulin therapy, hepatitis B virus (HBV) infection recurs in a high proportion of patients transplanted for HBsAg positive and serum HBV DNA negative chronic liver disease. The contribution of HBV genetic variability to disease recurrence has not been yet thoroughly addressed. We have therefore undertaken a detailed comparison of preS/S and preC/C sequences in two selected patients with recurrence of HBsAg and HBV DIVA after transplantation. Methods: PreS/S and preC/C regions were amplified by PCR from the serum, peripheral blood mononuclear...
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Source: Hepatitis Weekly (1997-03-31)
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