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Immunology (HCV)

"Lymphocyte and Macrophage Phenotypes in Chronic Hepatitis C Infection: Correlation with Disease Activity."

Published in Hepatitis Weekly, April 21st, 1997

According to the authors' abstract of an article published in American Journal of Pathology, "The pathogenesis of chronic hepatitis C and the mechanisms underlying progressive liver disease in patients with chronic hepatitis C infection are poorly understood. To demonstrate which inflammatory cells might be responsible for the necroinflammatory damage in chronic hepatitis C infection, we have correlated the phenotype of the intrahepatic lymphocytes and macrophages with histological activity in liver biopsy and explant specimens front 19 patients with chronic hepatitis C infection. In all stages of disease, more CD8+ than CD4+ lymphocytes were found. However,...

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