Immunology (HBV)

HBcAG and HBeAg Elicit Different Th Cell Subsets

Published in Hepatitis Weekly, April 21st, 1997

A report suggesting that T helper cells with the same specificity can develop into different T helper subsets based on the structural form of an immunogen may have a significant impact on the understanding of hepatitis B virus infection.

Among the unique characteristics of the hepatitis B virus (HBV) is the production of a secreted form of the nucleocapsid, HBV e antigen (HBeAg). The particulate nucleocapsid (HBV core antigen [HBeAg]) is an intracellular protein that encapsulates the viral DNA and plays an important role in the maturation of the virus. Non-particulate, secreted HBeAg, however, is not required for replication or infection.

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Source: Hepatitis Weekly (1997-04-21)

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