"Efficacy of a Virosome Hepatitis A Vaccine in an Endemic Region in Nicaragua: Interim Analysis of a Randomized Placebo-Controlled Trial."

According to an abstract submitted by the authors to the Fifth International Conference on Travel Medicine, held March 24-27, 1997, in Geneva, Switzerland, "Objectives: To determine the efficacy and side effects of a novel virosome-formulated hepatitis A vaccine (Epaxal Berna) among children in Leon, Nicaragua. Methods: Randomized, placebo-controlled, double-blind trial with total follow-up 15 months and planned interim analysis at 12 months. Seronegative children 18-72 months of age were identified using the EIA (Behring) test in capillary blood. Children were administered either placebo (P) or vaccine (V). Venous blood sampling was performed at time 0 (i.e., time at...

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