Virology (GBV-B)
"GB Virus B and Hepatitis C Virus NS3 Serine Proteases Share Substrate Specificity."
Published in Hepatitis Weekly, August 4th, 1997
According to the authors' abstract of an article published in Journal of Virology, "GB virus B (GBV-B) is a recently discovered virus responsible for hepatitis in tamarins (Saguinus species). GBV-B belongs to the Flaviviridae family and is closely related to the human pathogen hepatitis C virus (HCV). Nonstructural protein 3 (NS3) of HCV has been shown to encompass a serine protease domain required for viral maturation. GBV-B and HCV share only about 30% of the amino acid sequence within the NS3 protease domain. The catalytic triad is conserved, and the residue Phe-154, presumed to be a crucial amino acid for determining the S-1 specificity pocket of the HCV NS3 protease, is...
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Source: Hepatitis Weekly (1997-08-04)
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