Therapy (HCV)

Physicochemical Properties Affect IFN Efficacy

Published in Hepatitis Weekly, August 4th, 1997

The physicochemical properties of hepatitis C virus affect interferon therapy efficacy, especially in patients with genotype 1b, according to a report from Japan.

Recent reports suggest that viral subtype and serum viral levels are indicators of interferon response in patients with chronic hepatitis C virus (HCV) disease, but they are not accurate enough to predict the effectiveness of therapy.

The buoyant density of HCV has been estimated to be approximately 1.08 g/ml by sucrose density gradient equilibrium centrifugation (Bradley et al., 1991; and others). Hijikata et al. found that there is a close relationship between in vivo infectivity and the...

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Source: Hepatitis Weekly (1997-08-04)

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