Published in Hepatitis Weekly, August 18th, 1997
In those with hepatitis C virus (HCV) disease, several pretreatment factors are predictive of response to interferon (IFN) including baseline serum HCV RNA levels and HCV genotype. Recent studies showed that patients with HCV genotype 1a or 1b respond less favorably to IFN-(alpha) treatment (3 mIU tiw), with sustained response rates of less than 10 percent to 20 percent (Mahaney et al., Hepatology 1994;20:1405-1411; Yoshioka et al., Hepatology 1992;16:293-299).
"It is unknown whether a different dosing...
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