Pathogenesis (HBV)

Pre-S2 Protein Not Critical for Hepatitis B Infection

Published in Hepatitis Weekly, September 8th, 1997

Results of an in vivo study have confirmed earlier in vitro reports that the pre-S2 protein is not essential for hepatitis B virus infectivity.

Researcher Teresa Pollicino and colleagues also found that pre-S2 deficiency of infecting strains could have an etiopathogenetic role in acute liver failure.

"We might hypothesize that, since the T- and B-cell immunities specific for the pre-S2 protein are important early events in the human immune response to HBV infection, the absence of this protein may result in inefficient neutralization of the virus, favoring the more severe course of the infection," Pollicino et al. wrote ("Pre-S2 Defective Hepatitis B...

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Source: Hepatitis Weekly (1997-09-08)

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