Therapy (HBV)
"Hepatitis B Virus with Antigenically Altered Hepatitis B Surface Antigen Is Selected by High-Dose Hepatitis B Immune Globulin After Liver Transplantation."
Published in Hepatitis Weekly, March 16th, 1998
According to the authors' abstract of an article published in Hepatology, "'Escape' variants of hepatitis B virus (HBV) can cause infection despite previous immunization. These viruses show alterations of the immunogenic major hydrophilic loop of the HBV small surface protein (s-protein). We studied whether HBV 'escape' variants were selected in patients with graft infection after liver transplantation for HBV related diseases who received passive immunoprophylaxis with high-dose polyclonal hepatitis B hyperimmune globulin (HBIG). For that, pre-and posttransplantation sera of 34 patients were analyzed for the occurrence of HBV S-gene variants. In addition, binding of in...
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Source: Hepatitis Weekly (1998-03-16)
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