Disease Progression

Normal ALT Predicts Slower Fibrosis in HCV+

Published in Hepatitis Weekly, March 30th, 1998

The progression of fibrosis is almost twice as slow in hepatitis C virus infected persons with weak alanine aminotransferase (ALT), compared to those with elevated ALT, according to a report from France.

Researcher Philippe Mathurin and colleagues from the Hospitalier Pitie-Salpetriere also found that alcohol exacerbated fibrosis in those with weak ALT levels.

"We suggest that the natural history of infection in patients with persistently normal ALT is associated with a low risk of developing severe liver lesions, especially in patients without alcohol consumption," Mathurin et al. wrote ("Slow Progression Rate of Fibrosis in Hepatitis C Virus...

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Source: Hepatitis Weekly (1998-03-30)

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