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Diagnostics (HCV)

RIBA Testing Not Effective for Screening Anti-HCV Positive Patients

Published in Hepatitis Weekly, April 13th, 1998

Researchers in Denmark found that recombinant immunoblot assay (RIBA) was not particularly helpful in detecting hepatitis C RNA (HCV-RNA) in anti-HCV positive patients.

Based on their finding, they now test all anti-HCV positive cases for HCV-RNA using HCV-PCR (polymerase chain reaction).

Between May 1991 and August 1996, H.B. Krarup and colleagues at the Aalborg Hospital tested more than 4,300 anti-HCV (enzyme immunoassay [EIA]) positive patients using either RIBA-2 or RIBA-3, and HCV-PCR.

Although they found RIBA-3 produced fewer indeterminate results than RIBA-2 (5 percent compared to 9 percent), the trend was not statistically...

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