Blood Safety (HCV)
"Analysis of Hepatitis C Virus-inoculated Chimpanzees Reveals Unexpected Clinical Profiles."
Published in Hepatitis Weekly, May 4th, 1998
According to the authors' abstract of an article published in Journal of Virology, "The clinical course of hepatitis C virus (HCV) infections in a chimpanzee cohort was examined to better characterize the outcome of this valuable animal model. Results of a cross-sectional study revealed that a low percentage (39%) of HCV inoculated chimpanzees were viremic based on reverse transcription (RT-PCR) analysis. A correlation was observed between viremia and the presence of anti-HCV antibodies. The pattern of antibodies was dissimilar among viremic chimpanzees and chimpanzees that cleared the virus. Viremic chimpanzees had a higher prevalence of antibody reactivity to NS3, NS4, and NS5. ...
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Source: Hepatitis Weekly (1998-05-04)
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