"Broadly Reactive Antibodies to Hypervariable Region 1 in Hepatitis C Virus-Infected Patient Sera: Relation to Viral Loads and Response to Interferon."

According to the authors' abstract of an article published in Hepatology, "To clarify the nature of serum anti-hypervariable region 1 (HVR1) antibodies in patients infected with hepatitis C virus (HCV), we assessed the reactivity of 21 patients' sera with 42 HVR1 proteins by Western blot. HVR1 was expressed as fusion proteins with glutathione S-transferase (GST). The patients' sera reacted with variable percentages of the HVR1 proteins, and always reacted with HVR1 proteins of the different genotype. In the genotype-1b-infected patients, the percentage of genotype-lb HVR1 proteins reactive with serum correlated significantly with viral loads; the sera reactive with the higher...

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