Animal Studies (HBV)
"Lamivudine Therapy of WHV-Infected Woodchucks."
Published in Hepatitis Weekly, August 10th, 1998
According to the authors' abstract of an article published in Virology, "Hepatitis B viruses establish a chronic, productive, and noncytopathic infection of hepatocytes. Viral products are produced by transcription from multiple copies (5-50) of covalently closed circular (ccc) viral DNA. This cccDNA does not replicate, but can be replaced by DNA precursors that are synthesized in the cytoplasm. The present study was carried out to determine if long-term treatment with an inhibitor of viral DNA synthesis would lead to loss of virus products, including cccDNA, from the liver of woodchucks chronically infected with woodchuck hepatitis virus. Viral DNA synthesis was inhibited with the...
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Source: Hepatitis Weekly (1998-08-10)
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