Pathogenesis (HCV)

HCV Variants Circumvent CTL Activity

Published in Hepatitis Weekly, October 26th, 1998

There is only a narrow T-cell receptor repertoire responding to a single viral peptide/HLA ligand in hepatitis C virus, according to a report from Taiwan.

The emergence of hepatitis C virus (HCV) variants with altered peptide ligands as T-cell receptor (TCR) antagonists accompanied by a limited TCR repertoire may provide a mechanism for HCV chronicity," S.L. Tsai and colleagues wrote ("Hepatitis C Virus Variants Circumventing Cytotoxic T Lymphocyte Activity as a Mechanism of Chronicity," Gastroenterology, October 1998;115(4):954-965).

High rate of chronicity after acute HCV infection cannot be explained in the presence of a multispecific cytotoxic T...

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Source: Hepatitis Weekly (1998-10-26)

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