Therapy (HBV)

Combination Therapy Efficacious Against HBV

Published in Hepatitis Weekly, December 7th, 1998

The non-nucleoside agent robustaflavone appears to act synergistically with lamivudine and penciclovir in the treatment of hepatitis B virus.

Researcher D.E. Zembower and colleagues evaluated the activity of robustaflavone in the presence of more established therapies for hepatitis B ("Robustaflavone, A Potential Non-Nucleoside Anti-Hepatitis B Agent," Antiviral Research, August 1998;39(2):81-88).

Robustaflavone, a naturally occurring biflavanoid isolated from Rhus succedanea, was found to be a potent inhibitor of hepatitis B virus (HBV) replication in 2.2.15 cells, with an effective concentration (EC₅₀ ) of 0.25 microM, and a...

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Source: Hepatitis Weekly (1998-12-07)

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