Published in Hepatitis Weekly, December 21st, 1998
Researchers S. Das and M. Ott suggest that the inhibition of internal entry site-mediated translation by a small yeast RNA could block hepatitis C virus (HCV) replication.
The observation that poliovirus mRNA is not translated in the yeast Saccharomyces cerevisiae has led to the discovery of a small RNA (60 nt, called IRNA, inhibitor RNA) which was later shown to specifically inhibit internal ribosome entry site (IRES)-mediated translation of naturally uncapped mRNAs.
Translation of cellular capped mRNAs was not...
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Source: Hepatitis Weekly (1998-12-21)
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