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Genetics (HCV)

Novel Way to Block HCV Protein Synthesis Reported

Published in Hepatitis Weekly, December 21st, 1998

A newly reported genetic strategy may represent a novel way to stop hepatitis C virus protein synthesis.

Researchers S. Das and M. Ott suggest that the inhibition of internal entry site-mediated translation by a small yeast RNA could block hepatitis C virus (HCV) replication.

The observation that poliovirus mRNA is not translated in the yeast Saccharomyces cerevisiae has led to the discovery of a small RNA (60 nt, called IRNA, inhibitor RNA) which was later shown to specifically inhibit internal ribosome entry site (IRES)-mediated translation of naturally uncapped mRNAs.

Translation of cellular capped mRNAs was not...

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