Pathogenesis (HCV)

Lymphoid Cells May Explain Extrahepatic Dissemination

Published in Hepatitis Weekly, February 15th, 1999

Involvement of lymphoid cells in the early stages of hepatitis C virus infection may shed light into the pathogenesis of extrahepatic dissemination, according to a report from Italy.

Hepatitis C virus (HCV) is a single-stranded RNA agent which expresses its genetic information in the form of a single, large polyprotein encoded by an open reading frame (ORF) that extends through most of its genomic RNA ("Hepatitis C Virus Infection, Mixed Cryoglobulinemia, and Non-Hodgkin's Lymphoma: An Emerging Picture," Leuk Lymphoma, November 1998;31(5-6):463-476).

Proteolytic cleavage of the ORF product is essential for the virogenesis and the production of viral...

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Source: Hepatitis Weekly (1999-02-15)

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