Published in Hepatitis Weekly, February 15th, 1999
Hepatitis C virus (HCV) is a single-stranded RNA agent which expresses its genetic information in the form of a single, large polyprotein encoded by an open reading frame (ORF) that extends through most of its genomic RNA ("Hepatitis C Virus Infection, Mixed Cryoglobulinemia, and Non-Hodgkin's Lymphoma: An Emerging Picture," Leuk Lymphoma, November 1998;31(5-6):463-476).
Proteolytic cleavage of the ORF product is essential for the virogenesis and the production of viral...
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