Growth Factors

VEGF May Have Smaller Role Than flt-1 in Angiogenesis

Published in Hepatitis Weekly, February 22nd, 1999

In hepatocellular carcinoma, the receptor flt-1 may play a more important role in angiogenesis than vascular endothelial growth factor, study findings suggest.

Vascular endothelial growth factor (VEGF) and its receptors are important in angiogenesis in solid tumors to support growth beyond a minimal size. VEGF specifically acts on endothelial cells.

Irene O.L. Ng and colleagues studied the expression of VEGF and its receptor flt-1 in 50 cases of resected hepatocellular carcinomas (HCCs) ("Differential Higher Expression of VEGF-Receptor FLT-1 But Not VEGF Is Present in Hepatocellular Carcinoma," Hepatology, 1998;28(No.4, Pt.2):164A).

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Source: Hepatitis Weekly (1999-02-22)

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