Proteomics

Viral Killing Strategy Examined

Published in Hepatitis Weekly, February 22nd, 1999

A novel strategy for killing viral infected cells through transduction with protease-activated caspase-3 protein was presented by researchers from Missouri's Howard Hughes Medical Institute.

At present, treatment of HIV infection uses small inhibitory molecules that target HIV protease; however, the emergence of resistant HIV strains is increasingly problematic.

"To circumvent this, we report here a new 'Trojan horse' strategy to kill HIV infected cells by exploiting HIV protease," researcher A.M. Vocero-Akbani and colleagues wrote ("Killing HIV Infected Cells by Transduction with an HIV Protease-Activated Caspase-3 Protein," Nature Medicine, January...

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Source: Hepatitis Weekly (1999-02-22)

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