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Diagnostics (HCV)

"Peptide Analysis in NS5 Only RIBA Indeterminate Sera."

Published in Hepatitis Weekly, March 1st, 1999

According to an abstract submitted by the authors to the 51st Annual Meeting of the American Association of Blood Banks, held October 31 - November 4, 1998, in Philadelphia, Pennsylvania, "Background: Isolated NS5 reactivity in RIBA T11 is not associated with HCV infection. The addition of NS5 resulted in a new group of blood donors with false-positive results. Therefore, a peptide analysis of NS5 only reactive sera was performed. Methods: Panel A: voluntary blood donors (n=66), positive in consecutive 3rd-generation anti-HCV ELISAs (Ortho), and with an NS5 only reactivity in RIBA(TM)-3 (Chiron) but with a negative cDNA-PCR. Panel B: HCV infected blood donors (n=3),...

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