"Transfection of a Rat Hepatoma Cell Line With a Construct Expressing Human Liver Annexin V Confers Susceptibility to Hepatitis B Virus Infection."

According to the authors' abstract of an article published in Hepatology, "Previously, we have found that human liver annexin V (hA-V), in earlier reports referred as Endonexin II, is a specific hepatitis B surface antigen (HBsAg) binding protein. In this study, we demonstrate that transfection of rat hepatoma FTO 2B cells, a cell line that is not infectable by hepatitis B virus (HBV) and does not express hA-V, with a construct containing the hA-V gene, resulted in hA-V expressing cells susceptible to HBV infection. After in vitro infection, transfected FTO cells (assigned as FTO 9.1 cells) expressing hA-V in cultures were shown to contain HBV-precore/core,xmRNAs, and covalently closed...

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