Published in Hepatitis Weekly, March 8th, 1999
T. Wakita and colleagues developed approaches using antisense RNA to inhibit hepatitis C virus (HCV) RNA translation and HCV core protein expression ("Antiviral Effects of Antisense RNA on Hepatitis C Virus RNA Translation and Expression," Journal of Medical Virology, March 1999;57(3):217-222).
An HCV genotype 1b cDNA comprising nt 1-1321 or a fusion construct consisting of HCV (nt 1-584) and luciferase cDNAs were inserted downstream of T7 and CMV promoter sequences and used to generate HCV RNA...
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