"Residues Critical for Duck Hepatitis B Virus Neutralization Are Involved in Host Cell Interaction."

According to the authors' abstract of an article published in Journal of Virology, "To date, no detailed analysis of the neutralization properties of duck hepatitis a virus (DHBV) has been reported, and it is not clear whether any of the known neutralization epitopes correspond to the viral receptor binding site or to sequences involved in the cell entry pathway. We demonstrate here that antibodies directed against two overlapping peptides (amino acids 83 to 97 and 93 to 107), covering the sequences of most DHBV pre-S neutralizing epitopes, both inhibit virus binding to primary duck hepatocytes and neutralize virus infectivity. An extensive mutagenesis of the motif (WTP90)-W-88, which is...

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