Disease Progression

Allele May Play Role in HCV-Related Liver Disease

Published in Hepatitis Weekly, August 9th, 1999

The DQB1*0502 allele may have a role in promoting hepatitis C virus-related liver disease.

In this study, A. Mangia and colleagues from Italy's Hospital Casa Sollievo della Sofferenza sought to determine whether host-dependent genetic factors modulate the outcome of HCV infection ("HLA Class II Favors Clearance of HCV Infection and Progression of Chronic Liver Damage," Journal of Hepatology, June 1999;30(6):984-989).

HLA class II DRB and DQB typing was performed in 184 infected patients and 200 healthy volunteers. Among the patients, 149 subjects had persistent HCV viremia (Group 1) and 35 subjects underwent spontaneous viral clearance (Group...

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Source: Hepatitis Weekly (1999-08-09)

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