Genomics

Cyclin D1 Gene Plays Role in Hepatitis-Related Cancer

Published in Hepatitis Weekly, August 16th, 1999

Cyclin D1 gene expression appears to be involved in predisposing those with long-term hepatitis to cancer.

The interferon-gamma (IFN-gamma) transgenic mouse expresses the IFN-gamma gene strongly in the liver and develops chronic hepatitis from six to 10 weeks of age.

In earlier studies, T. Okamoto and colleagues from Japan's Nippon Chemipharmaceutical Company reported the detection of hepatocyte apoptosis and the expression of the Fas system in the transgenic mouse liver.

"The objective of the present study was to examine the possible development of favorable conditions for predisposing cells to malignancy," they wrote ("Long...

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Source: Hepatitis Weekly (1999-08-16)

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