Therapy (HBV)

Viral Titer Suppression in Serum of HBV Patients Examined

Published in Hepatitis Weekly, September 6th, 1999

Prolonged suppression of viral titers in the serum of hepatitis B patients may indicate the stability of hepatocyte infection rather than successful therapeutic outcome with lamivudine.

Alpha interferon (IFN-(alpha)) is the only drug widely used to treat virus carriers, but the response rate ranges around 20 percent. Lamivudine [(-)-(beta)-L-2',3'-dideoxy-3'-thiacytidine], a nucleoside analogue, has now been approved by the U.S. Food and Drug Administration for the treatment of hepatitis B. The administration of lamivudine induces a significant drop in the amount of virus in the serum of most HBV carriers and, unlike alpha interferon, causes no significant side...

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Source: Hepatitis Weekly (1999-09-06)

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