Drug Resistance

Natural Protein Pumps Nucleoside Analogs Out of Cells

Published in Hepatitis Weekly, September 27th, 1999

A cellular factor contributes to the failure of nucleoside-based antiviral drugs.

The finding has vast implications for AIDS therapy, which relies heavily on nucleoside-analog reverse-transcriptase inhibitors (NARTIs). It also raises questions about the nucleoside-based drugs used or under development for the treatment of hepatitis and cancer.

John D. Schuetz and colleagues of St. Jude Children's Research Hospital, Memphis, Tennessee, observed that the human T-lymphoid cell line CEM-r1 is resistant to the potent acyclic nucleoside analog PMEA. They found that this resistance was due to the cells' ability to get rid of the drug. Analysis showed...

Want to see the full article?

Purchase this article for only $3.00

We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.

Welcome to NewsRx!

Learn more about a six-week, no-risk free trial of Hepatitis Weekly

Source: Hepatitis Weekly (1999-09-27)

NewsRx is Social

Top Medical Newsletters

Awards

Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005

Facts & Stats

NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.

Google 2010 PageRank: #2 Among Top Health News and Media Publications
Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry