Disease Markers

HCV Replication in Liver Tissue Predicts Liver Injury

Published in Hepatitis Weekly, January 17th, 2000

Active replication of hepatitis C virus in liver tissue may determine the extent of liver injury.

Liver failure from chronic hepatitis C is the leading indication for liver transplantation in the United States. However, the pathogenesis of liver injury resulting from chronic hepatitis C virus (HCV) infection is not well understood.

"To examine the relationship between HCV replication in liver tissue and hepatocellular injury, a strand-specific in situ hybridization procedure was developed," M. Chang and colleagues from the University of Washington Medical Center wrote ("In situ Distribution of Hepatitis C Virus Replicative-Intermediate RNA in...

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Source: Hepatitis Weekly (2000-01-17)

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