Immunology

Anti-HCV Immune Response Key to IFN Success

Published in Hepatitis Weekly, January 24th, 2000

A patient's anti-hepatitis C virus-specific immune response may be the key to interferon response.

Hepatitis C virus (HCV) populations persist in vivo as a mixture of heterogeneous viruses called quasispecies. The relationship between the genetic heterogeneity of these variants and their responses to antiviral treatment remains to be elucidated.

In this study, K. Sandres and colleagues examined 26 virus strains to determine the influence of hypervariable region 1 (HVR-1) of the HCV genome on the effectiveness of alpha interferon (IFN-alpha) therapy ("Genetic heterogeneity of hypervariable region 1 of the hepatitis C virus (HCV) genome and...

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Source: Hepatitis Weekly (2000-01-24)

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