Virology

HCV Infection in PBMC Not Related to Viremia

Published in Hepatitis Weekly, January 24th, 2000

Hepatitis C virus infection of peripheral blood mononuclear cells is not a significant factor in virus-related viremia.

Although the liver is the main target for hepatitis C virus (HCV) infection, HCV RNA of positive and negative polarity has also been detected in peripheral blood mononuclear cells (PBMCs) by polymerase chain reaction. However, no data have been published on the relationship between the number of HCV-infected PBMCs and serum viremia levels.

"To address this issue, PBMC samples from 20 patients with chronic hepatitis C were examined by fluorescent in situ hybridization," E. Rodriguez-Inigo and colleagues wrote ("Fluorescent in situ...

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Source: Hepatitis Weekly (2000-01-24)

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