Virology

Binding Protein Stimulates Viral Sites Directed by Poliovirus

Published in Hepatitis Weekly, April 3rd, 2000

Scientists believe that polypyrimidine-tract binding protein (PTB) stimulates the translation of picornaviral and flaviviral RNAs, according to a study published in Molecular and Cellular Biology.

They believe this event occurs in vivo, based on the results of their study ("Transient expression of cellular polypyrimidine-tract binding protein stimulates cap-independent translation directed by both picornaviral and flaviviral internal ribosome entry sites in vivo," Mol Cell Biol, 2000;20(5):1583-1595).

R. Gosert and colleagues at the University of Texas conducted a study using a variety of plasmid transfected cells. The plasmids...

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Source: Hepatitis Weekly (2000-04-03)

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