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Vaccine Development

Hepatitis C Vaccine Represents Major Mutations in Isolates

Published in Hepatitis Weekly, July 24th, 2000

University of California at Davis medical researchers have developed a vaccine for the hepatitis C virus (HCV) that includes a significant number of mutations commonly found in a specific portion of the virus.

M.P. Carlos and colleagues reported their work at Immunology 2000, the Joint Annual Meeting of the American Association of Immunologists and the Clinical Immunological Society, held in Seattle, Washington. Describing the nature of the hepatitis C virus, Carlos et al. said, "Upon entry into its host, HCV undergoes a high rate of mutation resulting in marked sequence variation between isolates. These mutants account for the HCV persistence seen in infected...

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