Viral Replication

Distinct Membrane Association Patterns Noted in Mouse Hepatitis Virus Proteins

Published in Hepatitis Weekly, July 24th, 2000

Recent study findings from researchers at Vanderbilt University, Tennessee, have shown that gene 1 proteins in the mouse hepatitis virus can be found in distinctly different areas of cellular cytoplasm.

These findings suggest that gene 1 proteins have different roles that relate to viral infectivity, according to the investigators.

Writing in the Journal of Virology, A.C. Sims and colleagues noted that gene 1 proteins localize prominently on late endosomes, a site where viral RNA synthesis also takes place ("Mouse hepatitis virus replicase proteins associate with two distinct populations of intracellular membranes," J Virol,...

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Source: Hepatitis Weekly (2000-07-24)

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