Hepatocellular Carcinoma

p21 Protein Expression Linked to p53 Status

Published in Hepatitis Weekly, August 7th, 2000

Altered expression of the p53 protein has been associated with cancer activity for some time. Now medical researchers at the University of Tokyo in Japan show p21 (WAF1/CIP1) expression is linked to p53 status in patients with hepatocellular carcinoma (HCC).

This relationship was examined in 81 HCC tumors from 65 patients. "p21 (WAF1/CIP1) protein was absent from 59 of 81 tumors (72.8%), and altered p53 expression was found in 43 (53.1%)," Y.Z. Shi and study co-authors reported.

Of the 59 tumors in which p21 (WAF1/CIP1) was absent, 38 were also deficient in p53 expression, the researchers found ("Reduced p21 (WAF1/CIP1)...

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Source: Hepatitis Weekly (2000-08-07)

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