Viral Genomics

Substitutions in Internal Ribosome Entry Site of Hepatitis C Affect Replication

Published in Hepatitis Weekly, September 11th, 2000

Researchers at the University of Texas have added to the body of knowledge that suggests nucleotide substitutions on the internal ribosome entry site (IRES) of the hepatitis C virus (HCV) can enhance viral replication in certain types of cells.

In a study reported in 1996, N. Nakajima et al. found that three substitutions on the 5' nontranslated RNA region (5'NTR) of HCV occurred when H77 serum was inoculated into HCV infected lymphoblastoid cells (Journal of Virology, 1996;70:3325-3329)

According to H. Lerat and associates, writing in a recent issue of the Journal of Virology, this finding suggests that replication is increased in...

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Source: Hepatitis Weekly (2000-09-11)

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